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Drugs (such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, and hydroxychloroquine) that interfere with platelet-aggregation reactions may induce bleeding and should be used with caution in patients receiving heparin. It may be necessary to increase doses of heparin in the febrile state.
Digitalis, tetracycline, nicotine, or antihistamines may partially counteract the anticoagulant action of heparin sodium. An increased resistance to the drug is frequently encountered in thrombosis, thrombophlebitis, infection with thrombosing tendencies, myocardial infarction, cancer, and postsurgical patients.
